Well I am in the Harry Callahan (as in Dirty Harry) camp:
Model 460 XVR Revolver
We all grew up hearing the phrase, “Faster than a speeding bullet...,” but not when it is fired from Smith & Wesson’s new Model 460XVR, with the highest muzzle velocity of any production revolver on earth. The Model 460XVR is so revolutionary that it required an entirely new designation...XVR, X-treme Velocity Revolver.
Starting with their Extra Large Frame, the Smith & Wesson engineers worked to deliver maximum velocity - over 2,300 feet per second - to reach the target faster than ever before. The 460XVR has interchangeable compensators to accommodate every load and includes a HI-VIZ® front sight for accurate target acquisition. Plus, its “gain-twist” rifled barrel means superb long-range accuracy (beyond 200 yards) with every shot! Only Smith & Wesson could deliver this much power, this much velocity and this much accuracy in a precision, production revolver.
* Removable, Interchangeable Compensator
* The Highest Velocity Revolver in the World - 2330 FPS/200 Grain!
* The Most Powerful .45 Caliber Revolver In the World - 2400 lbs/ft!
* If You Zero its Sights at 200 Yards You Will Bag Your Buck with a Center Hold 0-250 Yards with No Hold Over! Just Center It and Fire. The 460XVR Will Do The Rest
* Gain Twist Rifled Barrel for Superb Accuracy
* Lighter Loads That The 460 Will Also Fire Include .45 Colt and .454 Casull
* Incredibly Low Perceived Recoil For All Loads
* Manufacturers Suggested Retail Price: $1313.00 (and worth every penny)